BDBM103302 SCH772984::US8546404, 6
SMILES O=C(CN1CC[C@@H](C1)C(=O)Nc1ccc2[nH]nc(-c3ccncc3)c2c1)N1CCN(CC1)c1ccc(cc1)-c1ncccn1
InChI Key InChIKey=HDAJDNHIBCDLQF-RUZDIDTESA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 2 hits for monomerid = 103302
TargetSerine/threonine-protein kinase haspin [465-798](Homo sapiens (Human))
George Washington University
George Washington University
Affinity DataIC50: 398nMAssay Description:The IC50 values of selected kinases were determined using either Z'LYTE, Adapta or LanthaScreen assays.More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase haspin [465-798](Homo sapiens (Human))
George Washington University
George Washington University
Affinity DataKd: 297nMpH: 7.5 T: 2°CAssay Description:For ERK1 and ERK2, the buffer contained 20 mM HEPES (pH 7.5), 150 mM NaCl and 0.5 mM TCEP. For haspin, the buffer contained 20 mM HEPES (pH 7.5), 250...More data for this Ligand-Target Pair
Activity Spreadsheet -- ITC Data from BindingDB
Found 1 hit for monomerid = 103302
ITC DataΔG°: -8.66kcal/mole −TΔS°: 8.95kcal/mole ΔH°: -17.6kcal/mole logk: 3.71E+6
pH: 7.5 T: 15.00°C
pH: 7.5 T: 15.00°C